Some Studies on the Naturally Occurring Leucocyte
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چکیده
The purpose of this report is to describe some investigations which attempt to define the nature and incidence of naturally occurring leucocyte agglutinins. Agglutinins have been demonstrated in the sera of patients with acquired hemolytic anemia (1) and thrombocytopenic purpura (2, 3) and these have been distinguished from naturally occurring anti-red cell (4) and anti-platelet (5) agglutinins. Leucocyte agglutinins have been demonstrated in various clinical conditions including lupus erythematosus (6), aleukemic leukemia (6), pancytopenia (6, 7), agranulocytosis due to pyramidon (8) and chronic neutropenia (9). Some have implicated these agglutinins as the causative factors for the leukopenia in these diseases. Goudsmit and van Loghem (6) tested the sera of 100 healthy donors against type 0 white cells. They found weakly positive clumping reactions in 10 instances. Dausset, Nenna, and Brecy (10) studied the sera of 300 normal donors for the presence of agglutinins to compatible leucocyte suspensions and failed to demonstrate any. Dausset (11) cited some unpublished experiments in collaboration with van Loghem in which combinations of 50 normal sera and 50 corresponding varieties of white cells were tested for leucocyte agglutination. They observed frequent but inconstant agglutinations in the combinations which were incompatible for the ABO blood groups. Moeschlin and Schmid (12) tested blood samples of 30 persons in 380 leucocyte serum combinations without regard for A, B and 0 blood groups. They noted leucocyte agglutination in 60 cases of
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تاریخ انتشار 2013